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EDITORIALS

COVID-19 and the cardiovascular system

The understanding of the pathophysiology of cardiovascular complications in COVID-19 is a key to the implementation of therapeutic measures, which may offer additional benefits, mainly for patients with severe disease, such as anticoagulants.

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CASE REPORT

Severe bradyarrhythmia requiring temporary pacemaker in a COVID-19 patient receiving lopinavir/ritonavir treatment: a case report

This case highlights it is necessary to investigate balance between efficacy and safety of lopinavir/ritonavir for COVID-19 therapy. Off –label prescribing lopinavir/ritonavir outside of a clinical trial setting should be avoided until the data have proven that treatment benefit over placebo.

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REVIEW

Athletic heart adaptation, pathological hypertrophy and sudden cardiac death

In this review, we aimed to represent recent physiological and clinical standpoints regarding to athletic heart syndrome as well as its difference from sedentary heart changes and pathological hypertrophy, its association with sudden cardiac death.

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ORIGINAL RESEARCH ARTICLE

Remodeling of the left heart in patients with rheumatic mitral valve disease after mitral valve replacement with preservation of subvalvular structures

This study shows the possibility of implanting the right size of the artificial heart valve, with rheumatic lesions of the mitral valve with the complete preservation of subvalvular structures.

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ORIGINAL RESEARCH ARTICLE

Atrial septal defect patients with greater shunts show susceptibility for ventricular arrhythmias

T wave peak-to-end interval is a measure of transmural dispersion of repolarization and accepted as a surrogate for increased ventricular arrhythmogenesis risk. Our findings show that ASD patients whose shunt ratio are ≥2.0 show increased risk for arrhythmias.

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REVIEW

Arrhythmias in COVID-19: clinical significance and management

Worldwide spread of coronavirus disease (COVID-19) caused overwhelming mortality rate during preceding half of the year 2020. Although coronavirus infection was known for mostly respiratory tract involvement, novel COVID-19 pandemic showed excessive cardiac mortality and arrhythmic complications. We aimed to summarize current literature and emphasize on underlying pathological mechanisms and global point of view to coronavirus and arrhythmia relationship.

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EDITORIALS

From Editor-in-Chief: Has everything changed during pandemic: peer-review, science, clinical practices and education, CV diseases?

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IMAGE

CT and MR images of cystic adventitial disease of the popliteal artery

Cystic adventitial disease (CAD) is a very rare vascular disorder with prevalence as low as 1:1000 of all vascular pathologies (1). This disease most frequently occurs in young or middle-aged male patients with male/female ratio of 5/1

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ORIGINAL RESEARCH ARTICLE

The effects of tocilizumab on clinical and laboratory features of patients with severe COVID-19: a single-center experience

Our observational study demonstrated significant improvement in oxygen saturation, reduction in inflammatory markers – leukocytosis, CRP and D-dimers and 83% recovery without need for mechanical ventilation and no mortality in patients with COVID-19 with severe multilobar bilateral pneumonia and CT score 3-4 receiving tocilizumab in addition to standard treatment.

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ORIGINAL RESEARCH ARTICLE

Assessment of cardiovascular risk in Kyrgyz Republic

An analysis of the current situation in the Kyrgyz Republic demonstrates that the areas of concern in care system for patients with cardiovascular diseases (CVD) are the insufficient and untimely identification of cardiovascular risk factors, as well as their ineffective management due to the incomplete implementation of existing risk stratification guidelines and decision-making. This study assesses distribution of total cardiovascular risk among the population of the Kyrgyz Republic using the WHO/ISH risk scale. In addition, the distribution of the main risk factors separately is calculated, as well as the frequency of some additional CVD risk factors that are not included into the WHO/ISH evaluation scale is estimated.

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CASE REPORT

Texidor’s twinge a rare cause of benign paroxysmal chest pain

Various maneuvers like lying down or sitting upright and attempting deep inspiration tends to help in such conditions. This case report is reporting an unusual presentation of this syndrome due to its long duration of episode than the duration described in the previous reports.

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CASE REPORT

Acute coronary syndrome, a rare manifestation of infective endocarditis: a case report

Presentation of an acute coronary syndrome related to infective endocarditis is rare but potentially lethal. For young people, acute myocardial infarction and an infection syndrome should lead us to suspect IE.

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SYSTEMATIC REVIEW

His Bundle Pacing – Stand-alone or adjunctive physiological pacing: a systematic review

His-bundle pacing (HBP) appears to be a viable stand-alone or adjunctive physiological pacing therapy in pacemaker dependent patients. It could also serve as an effective adjunct or alternative pacing therapy for heart failure patients who require cardiac resynchronization therapy or pacemaker upgrade. His-bundle pacing has demonstrated improvement of His-Purkinje conduction, left ventricular electrical / mechanical synchronization, and left ventricular ejection fraction (LVEF) compared with right ventricle pacing.

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CASE REPORT

Sudden cardiac arrest after late permanent pacemaker implantation in a heart transplant patient

Bradycardia during the early period following heart transplantation frequently occurs with an incidence of 14 to 44% and it is usually self-limited. The incidence of late bradycardia (from 30 days to more than 5 or 6 months after transplantation) has been reported to be 1.5%. A 33-year-old male patient with a history of orthotopic heart transplantation in 2013 presented with complaints of dizziness and near syncope. A DDDR permanent pacemaker was implanted for sinus pauses exceeding 3 seconds recorded on Holter examination. Shortly after the procedure, he developed sudden cardiovascular collapse. Cardiopulmonary resuscitation was performed and a pulse steroid treatment (2 grams of methylprednisolone) was given. After 2 days, the patient was extubated. While making preparations for re-transplantation, cardiopulmonary arrest developed again and he died. Sinus pause may be a clue for rejection and is an important finding in predicting clinical course.

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CASE REPORT

Anatomy of the retrograde type A aortic dissection after endovascular repair of type B aortic dissection: a case report

We report a case of a 55-year-old gentleman who had undergone thoracic EVAR. Thirty months after the given procedure he presented with RTAD and underwent supracoronary aortic replacement. The article is intended to remind the clinicians of the importance of early detection of the possible complications when performing EVAR, and the significance of a rapid response.

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CASE REPORT

A case of undifferentiated pleomorphic cardiac sarcoma

We present a case of a 78-year-old female patient who was admitted to our hospital with progressive dyspnea and chest pain. Echocardiography revealed multiple masses of different shape and size in the left atrium, the left and right ventricles. Cardiac magnetic resonance confirmed multiple cardiac masses with signs of invasion in the myocardium and heterogeneous late gadolinium enhancement in all these masses. A biopsy of the abdominal mass revealed an undifferentiated pleomorphic sarcoma.

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EDITORIALS

What is new in cardiac pacing ESC guidelines 2021?

New sections have appeared concerning patient workout before implantation, but also concerning the new modalities of conduction system pacing, and a new section on perioperative management. We summarize here the key points from these International guidelines.

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ORIGINAL RESEARCH ARTICLE

The evaluation of cTnT/CK-MB ratio is as a predictor of change in cardiac function after myocardial infarction

The cTnT/CK-MB ratio was superior to its components in predicting changes in LV function after STEMI. The cTnT/CK-MB ratio can be used in clinical practice for risk stratification and treatment optimization.

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EDITORIALS

New in the diagnosis of heart failure and management of associated conditions in 2021 ESC guidelines

Heart failure (HF) is a major health problem affecting millions of people worldwide. The report about heart disease and stroke statistics claimed that almost 6.0 million Americans ≥20 years of age had HF based on the results of 2015-2018 The National Health and Nutrition Examination Survey (NHANES) (1)

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